Graveoline (Standard)

Graveoline (Standard) is the analytical standard of Graveoline (HY-12538) . This product is intended for research and analytical applications. Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candida albicans. Graveoline can be used in the research of various diseases such as tumors and liver injury[1][2].

Product Specifications

CAS Number

[485-61-0]

UNSPSC

12352100

Target

Apoptosis; Autophagy; Fungal; Interleukin Related; JAK; Parasite; Reactive Oxygen Species (ROS) ; Reference Standards; STAT

Related Pathways

Anti-infection; Apoptosis; Autophagy; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer; Infection; Inflammation/Immunology

Smiles

O=C1C=C(C2=CC=C(OCO3)C3=C2)N(C)C4=C1C=CC=C4

Molecular Formula

C17H13NO3

Molecular Weight

279.30

References & Citations

[1]Ghosh S, et, al. Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. Phytother Res. 2014 Aug;28 (8) :1153-62.|[2]Kamal LZM, et, al. Identification of Alkaloid Compounds Arborinine and Graveoline from Ruta angustifolia (L.) Pers for their Antifungal Potential against Isocitrate lyase (ICL1) gene of Candida albicans. Mycopathologia. 2021 May;186 (2) :221-236.