NPD4456

NPD4456 (Compound 3) is a 3-phenylcoumarin Vpr inhibitor. NPD4456 binds to Vpr in a competitive manner. NPD4456 inhibits HIV-1 viral infection[1].

Product Specifications

CAS Number

[859668-98-7]

UNSPSC

12352005

Hazard Statement

H400

Target

HIV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(OC1=CC=C(C(O2)=C1)C(C)=C(C3=CC(OC)=CC=C3OC)C2=O)N(C)C

Molecular Formula

C21H21NO6

Molecular Weight

383.39

Precautions

P273-P391-P501

References & Citations

[1]Ong EB, et al. Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR. J Biol Chem. 2011 Apr 22;286 (16) :14049-56.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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