MRK-A
MRK-A is a selective, blood-brain-barrier permeable mutant IDH1 inhibitor with an IC50 value of 5 nM. MRK-A inhibits 2-HG production. MRK-A has anti-cancer activity against brain tumors[1].
Product Specifications
CAS Number
[1934301-68-4]
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(N1CC2=CC=CN=C2NC3=CC=C(N4CCOCC4)C=C13)C5CCC6=CC=CC=C6CC5
Molecular Formula
C28H30N4O2
Molecular Weight
454.56
References & Citations
[1]Kopinja J, et al. A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit. Sci Rep. 2017 Oct 23;7 (1) :13853.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
