ML279
ML279 is a potent scavenger receptor, class B, type I (SR-BI) inhibitor. ML279 can inhibit SR-BI-mediated lipid uptake by stabilizing the binding of HDL to SR-BI (EC50 = 0.27 μM) . ML279 can be used for the researches of infection and cardiovascular disease, such as atherosclerosis and HCV infection[1].
Product Specifications
CAS Number
[1604821-55-7]
UNSPSC
12352005
Target
HCV; Scavenger Receptor Class B type I (SR-BI)
Related Pathways
Anti-infection; Immunology/Inflammation
Field of Research
Infection; Cardiovascular Disease
Smiles
O=C(N(C1CCCCC1)[C@H](C)C(NC2CCCC2)=O)CN3N=C(C4=CC=C(OCO5)C5=C4)N=N3
Molecular Formula
C24H32N6O4
Molecular Weight
468.55
References & Citations
[1]Dockendorff C, et al. Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI) -mediated lipid uptake. Bioorg Med Chem Lett. 2015 Jun 15;25 (12) :2594-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
