S1PL-IN- 2

S1PL-IN-2 (Compound 28) is a potent sphingosine-1-phosphate lyase (S1PL) inhibitor with an IC50 of 120 nM. S1PL-IN-2 shows an IC50 of 230 nM on HEK293 cells. S1PL-IN-2 block the conversion of Vitamin B6 into the active pyridoxal-4-phosphate cofactor required for S1P lyase activity. S1PL-IN-2 can be used for the researches of inflammation and immunology, such as rheumatoid arthritis[1].

Product Specifications

CAS Number

[1897406-94-8]

UNSPSC

12352005

Target

LPL Receptor

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=NOC(C)=C1)NC(C2=CC=CC=C2)CNCC3=CC(C)=C(OCCCC)C=C3C

Molecular Formula

C26H33N3O3

Molecular Weight

435.56

References & Citations

[1]Dinges J, et al. Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors. Bioorg Med Chem Lett. 2016 May 1;26 (9) :2297-302.