ADM 12

ADM 12 is a highly selective transient receptor potential ankyrin 1 (TRPA1) channel antagonist. ADM 12 blocks nitroglycerin (NTG) -induced trigeminal hyperalgesia in animal models, reducing expression of pain-related genes (c-Fos, TRPA1) and neuropeptides (CGRP, SP) . ADM_12 is promising for research of migraine and neuropathic pain[1].

Product Specifications

CAS Number

[1644134-60-0]

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=S(CCCNC(CCCCC1SSCC1)=O)(O)=O

Molecular Formula

C11H21NO4S3

Molecular Weight

327.48

References & Citations

[1]Demartini C, et al. The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model. J Headache Pain. 2017 Sep 7;18 (1) :94.