CAM4066

CAM4066 is a potent CK2α inhibitor, with an IC50 value of 300 nM. CAM4066 exhibits high selectivity, with IC50 values of 22.35, 43.55, and > 50 μM for HIPK3, DAPK3, and CLK2, respectively. CAM4066 shows no cell activity. CAM4066 can be used for the development of highly potent CK2 inhibitors[1].

Product Specifications

CAS Number

[2101206-81-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Casein Kinase

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(O)C1=CC=CC(NC(CCNC(CCNCC2=CC=C(C3=CC=CC=C3)C(Cl)=C2)=O)=O)=C1

Molecular Formula

C26H26ClN3O4

Molecular Weight

479.96

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Glossop PA, et al. Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors. J Med Chem. 2025 Oct 23;68 (20) :21587-21614.