MK-8325

MK-8325 (Compound 1) is an orally active HCV NS5A inhibitor. MK-8325 exhibits minimal inhibitory activity against hERG at a concentration of 30 mM. MK-8325 may be used in hepatitis C research[1].

Product Specifications

CAS Number

[1334312-52-5]

UNSPSC

12352005

Target

HCV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(OC)N[C@@H](C(C)C)C(N1C[Si](C)(C)C[C@H]1C2=NC3=CC=C4C=C(C5=CC=C(C6=CN=C([C@H]7N(C([C@H](C(C)C)NC(OC)=O)=O)CC(F)(F)C7)N6)C=C5)C=CC4=C3N2)=O

Molecular Formula

C43H52F2N8O6Si

Molecular Weight

843.01

References & Citations

[1]Nair AG, et al. MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV. Bioorg Med Chem Lett. 2018 Jun 1;28 (10) :1954-1957.