MK-761 (TFA)

MK-761 TFA is a potent and orally active β2-adrenergic blocker. MK-761 TFA shows antihypertensive and positive inotropic effects. MK-761 TFA shows vasodilating properties[1].

Product Specifications

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

99.93

Smiles

N#CC1=CC=CN=C1OC[C@H](CNC(C)(C)C)O.O=C(C(F)(F)F)O

Molecular Formula

C15H20F3N3O4

Molecular Weight

363.33

References & Citations

[1]Scriabine A, et al. Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs. Experientia. 1979 Dec 15;35 (12) :1634-7.|[2]C.S. Sweet, et al. Peripheral Vasodilator and β-Adrenoceptor Blocking Properties of Several β-Adrenoceptor Antagonists. Clinical and Experimental Hypertension. 2009, 449-471.|[3]Sweet CS, et al. Beta adrenoceptor blocking properties of MK-761. J Pharmacol Exp Ther. 1979 Oct;211 (1) :195-9.