LN-1-255 (sodium)
LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC50 for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs[1][2].
Product Specifications
CAS Number
[247115-03-3]
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C([C@@H]([C@](C)(COC(CC1=CC=C(O)C(O)=C1)=O)S([C@]2([H])/C3=C\C4=NC=CC=C4)(=O)=O)N2C3=O)O[Na]
Molecular Formula
C22H19N2NaO9S
Molecular Weight
510.45
References & Citations
[1]Vallejo JA, et al. LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48. J Antimicrob Chemother. 2016 Aug;71 (8) :2171-80.|[2]Vázquez-Ucha JC, et al. Activity of the β-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii. Antimicrob Agents Chemother. 2017 Oct 24;61 (11) :e01172-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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