RX 336M

RX 336M is a dihydrocodeinone analogue. RX 336M induces behaviors consisting of consisting of behavioral activation, rapid forepaw movements, excessive grooming, and whole body "wet-dog" shakes (WDS) (rapid twisting of the head and trunk with the forepaws leaving the ground) . RX 336M can be used for the study of neurological disease[1][2].

Product Specifications

CAS Number

[6701-66-2]

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Field of Research

Neurological Disease

Smiles

O=C1C2OC3=C(C=CC(CC4C5(C6C1)CCC(C)=C6C)=C3C25CCN4C)OC

Molecular Formula

C24H29NO3

Molecular Weight

379.49

References & Citations

[1]Lee EJ, et al. Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC. Clin Cancer Res. 2024 Apr 15;30 (8) :1582-1594. |[2]Isaacson RL, et al. Age- and sex-related induction of excessive grooming and "wet-dog" shakes by the codeinone RX 336-M in the rat. Behav Neural Biol. 1987 May;47 (3) :250-61.