DMP 904
DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity[1][2].
Product Specifications
CAS Number
[202579-74-6]
UNSPSC
12352005
Target
Adenylate Cyclase; CRFR
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Smiles
CC1=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN2C(NC(CC)CC)=C1
Molecular Formula
C21H28N4O
Molecular Weight
352.47
References & Citations
[1]Li YW, et al. The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists. CNS Drug Rev. 2005 Spring;11 (1) :21-52.|[2]Nielsen DM, et al. Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. Eur J Pharmacol. 2004 Sep 19;499 (1-2) :135-46.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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