GEBR-7b

GEBR-7b is a selective PDE4D inhibitor with an IC50 of 0.67 μM. GEBR-7b increases hippocampal cAMP and does not influence Aβ levels in rodents. GEBR-7b also improves spatial and can be used for the study of cognitive deficits[1][2].

Product Specifications

CAS Number

[1776944-03-6]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Smiles

COC1=CC=C(C=C1OC2CCCC2)/C=N/OCC(N3CC(C)OC(C)C3)=O

Molecular Formula

C21H30N2O5

Molecular Weight

390.47

References & Citations

[1]Bruno O, et al. New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms. J Med Chem. 2009 Nov 12;52 (21) :6546-57.|[2]Bruno O, et al. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011 Dec;164 (8) :2054-63.