L 689660 (maleate)

L 689660 maleate, a cholinomimetic agent, is a selective M1 and M3 muscarinic receptors agonist. L 689660 maleate is a potent M1 muscarinic receptor full agonist in the rat superior cervical ganglion (pEC50 of 7.3) . L 689660 maleate is a potent M3 receptors agonist in the guinea-pig ileum myenteric plexus-longitudinal muscle or in trachea (pEC50 of 7.5 and 7.7, respectively) [1][2].

Product Specifications

CAS Number

[144860-79-7]

UNSPSC

12352100

Hazard Statement

H302-H315-H319

Target

MAChR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

ClC1=CN=CC(C2CN3CCC2CC3)=N1.O=C(/C=C\C(O)=O)O.[x]

Molecular Formula

C15H18ClN3O4

Molecular Weight

339.77

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Hargreaves RJ, et al. L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br J Pharmacol. 1992 Oct;107 (2) :494-501.|[2]Aagaard P, et al. Pharmacological characterization of the novel cholinomimetic L-689,660 at cloned and native brain muscarinic receptors. J Pharmacol Exp Ther. 1993 Dec;267 (3) :1478-83.