Sudemycin E
Sudemycin E is an analog of FR901464 (HY-16212) . Sudemycin E can induce reversible changes in alternative splicing and abnormalities in chromatin modifications by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein (snRNP), thereby leading to the death of cancer cells. Sudemycin E has anti-tumor activity and can be used in tumor research[1].
Product Specifications
CAS Number
[1197054-49-1]
UNSPSC
12352005
Target
SF3B1
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
CC(C)C(O[C@@H](C)/C=C\C(N[C@@H](CO1)CO[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(CC(C)(O2)C)CO3)=O)=O
Molecular Formula
C27H41NO7
Molecular Weight
491.62
References & Citations
[1]Convertini P, et al. Sudemycin E influences alternative splicing and changes chromatin modifications. Nucleic Acids Res. 2014 Apr;42 (8) :4947-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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