NC-001
NC-001 is a selective apoptosis inducer targeting renal proximal tubular cells and renal cancer cells. NC-001 inhibits tumor growth in clear cell renal cell carcinoma (CCRCC) xenograft models. NC-001 is promising for research of metastatic renal cell carcinoma[1].
Product Specifications
CAS Number
[1237540-68-9]
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C([C@H]1N(C([C@H](C)NC(CN=[N+]=[N-])=O)=O)CCC1)N[C@@H](CCCC)C(N[C@@H](CC(C)C)C([C@]2(C)OC2)=O)=O
Molecular Formula
C25H41N7O6
Molecular Weight
535.64
References & Citations
[1]Hedman H, et al. Abstract LB-118: NC-001 induces apoptosis and necrosis in clear cell renal cell carcinoma in vitro and in a xenograft model in vivo[J]. Cancer Research, 2012, 72 (8_Supplement) : LB-118-LB-118.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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