RWJ 29009
RWJ 29009 is a highly selective ATP-sensitive potassium channel agonist. RWJ 29009 activates potassium channel in vascular smooth muscle cells, promoting potassium efflux and membrane hyperpolarization to induce coronary and peripheral vasodilation. RWJ 29009 is promising for research of cardiovascular diseases such as acute myocardial ischemia and hypertension[1].
Product Specifications
CAS Number
[143164-10-7]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
O=C1N(CCCC1)[C@@H]2C3=C(OC(C)([C@H]2O)C)C=C(S3)[N+]([O-])=O
Molecular Formula
C14H18N2O5S
Molecular Weight
326.37
References & Citations
[1]Damiano BP, et al. In vivo cardiac electrophysiologic effects of RWJ 29009, a new potassium-channel activator, in comparison to cromakalim and nicardipine. J Cardiovasc Pharmacol. 1993 Jul;22 (1) :143-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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