BAY-386
BAY-386, a chemical probe, is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC[1].
Product Specifications
CAS Number
[1256941-06-6]
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N1C[C@@H](C2=NC(C3CC3)=NO2)C[C@@H](C4=CC=C(OC(F)(F)F)C=C4)C1)N5CCS(CC5)(=O)=O
Molecular Formula
C22H25F3N4O5S
Molecular Weight
514.52
References & Citations
[1]Santos S R F. Impact of PAR-1 upregulation upon EXT-1kd on balancing resistance and platelet activation[D]. Universidade de Lisboa (Portugal), 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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