BMS-182264

BMS-182264 is a highly selective ATP-sensitive potassium channel agonist. BMS-182264 promotes potassium efflux and membrane hyperpolarization to induce smooth muscle relaxation and vasodilation. BMS-182264 is promising for research of cardiovascular diseases such as hypertension and myocardial ischemia[1][2].

Product Specifications

CAS Number

[127749-54-6]

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Smiles

N#CN/C(NC(C(C)(C)C)C)=N\C1=CC=C(C=C1)C#N

Molecular Formula

C15H19N5

Molecular Weight

269.34

References & Citations

[1]Dickinson KE, et al. Identification of [3H]P1075 binding sites and P1075-activated K+ currents in ovine choroid plexus cells. Eur J Pharmacol. 1998 Mar 12;345 (1) :97-101.|[2]Atwal KS. Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers. J Cardiovasc Pharmacol. 1994;24 Suppl 4:S12-7.