IDN-1965

IDN-1965 is an irreversible, broad-spectrum caspase inhibitor. IDN-1965 prevents downstream apoptotic events (such as DNase activation) and significantly delays cytochrome c release by inhibiting caspase activity. IDN-1965 significantly delayed death in mice with cardiomyocyte apoptosis. IDN-1965 completely prevents left ventricular dilation, systolic dysfunction, and fibrosis in mice with dilated cardiomyopathy. IDN-1965 can be used to study apoptosis-related diseases such as heart failure and the mechanisms of apoptosis initiation[1][2].

Product Specifications

CAS Number

[204919-14-2]

UNSPSC

12352005

Target

Apoptosis; Caspase

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Smiles

O=C(CC(C(CF)=O)NC([C@H](C(C)C)NC(C(N1C)=C(C2=C1C=CC=C2)C)=O)=O)O

Molecular Formula

C21H26FN3O5

Molecular Weight

419.45

References & Citations

[1]Wencker D, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest. 2003 May;111 (10) :1497-504.|[2]Marsden VS, et al. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature. 2002 Oct 10;419 (6907) :634-7.