GSK-340
GSK-340 is a BET inhibitor with high affinity and significant selectivity for BD2 from BRD4 with a pIC50 of 7.2. GSK-340 inhibits MCP-1 release in Lipopolysaccharide (HY-D1056) treated PBMCs and whole blood with the pIC50 of 7.4 and 6.0, respectively. GSK-340 has immunomodulatory activity[1].
Product Specifications
CAS Number
[2222509-79-5]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Related Pathways
Epigenetics
Field of Research
Inflammation/Immunology
Smiles
CC(N1[C@@H](C2CC2)CN(CC3=CC=CC=C3CO)C4=C1C=CC(C5=CCNCC5)=C4)=O
Molecular Formula
C26H31N3O2
Molecular Weight
417.54
References & Citations
[1]Law RP, et al. Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain. J Med Chem. 2018 May 24;61 (10) :4317-4334.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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