Setoperone
Setoperone is an orally active and potent 5-HT₂ receptor antagonist and a moderate dopamine D₂ receptor blocker. Setoperone dissociates from the receptors relatively quickly, but it is easily "captured" by serotonin receptors in the body, resulting in persistent receptor inhibition even after elution. Setoperone can be used to study the negative symptoms of type II schizophrenia and associated mood disorders[1][2].
Product Specifications
CAS Number
[86487-64-1]
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1C(CCN2CCC(CC2)C(C3=CC=C(C=C3)F)=O)=C(N=C4N1CCS4)C
Molecular Formula
C21H24FN3O2S
Molecular Weight
401.50
References & Citations
[1]Ceulemans DL, et al. Effect of serotonin antagonism in schizophrenia: a pilot study with setoperone. Psychopharmacology (Berl) . 1985;85 (3) :329-32. |[2]Leysen JE, et al. Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: ritanserin and setoperone. Psychopharmacology (Berl) . 1986;88 (4) :434-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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