Nitroparacetamol
Nitroparacetamol (NCX-701) is a nitric oxide (NO) donor-non-steroidal anti-inflammatory agent (NO-NSAID) . Nitroparacetamol is formed by the ester linkage of Acetaminophen (HY-66005) and Nitrooxybutyroyl, aiming to combine the analgesic advantage of Acetaminophen with the organ-protective effect of nitric oxide, while expanding its anti-inflammatory activity. The analgesic spectrum of Nitroparacetamol is broader, and it is effective for painful pathological pain, and significantly reduces hepatotoxicity. Nitroparacetamol can reduce the expressions of IL-1β, TNF-α, COX-2, and iNOS.
Product Specifications
CAS Number
[326850-30-0]
Product Name Alternative
NCX-701
UNSPSC
12352005
Target
COX; Interleukin Related; NO Synthase; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(CCCO[N+]([O-])=O)OC1=CC=C(C=C1)NC(C)=O
Molecular Formula
C12H14N2O6
Molecular Weight
282.25
References & Citations
[1]Romero-Sandoval EA, et al. Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics. CNS Drug Rev. 2007 Fall;13 (3) :279-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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