Amonafide (L-malate)

Amonafide L-malate is a topoisomerase II inhibitor and DNA intercalator that induces Apoptotic signaling by blocking the binding of Topo II to DNA[1][2][3].

Product Specifications

CAS Number

[618863-54-0]

Product Name Alternative

AS-1413 (L-malate)

UNSPSC

12352005

Target

Apoptosis; DNA Alkylator/Crosslinker; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC(C[C@H](O)C(O)=O)=O.O=C1C2=CC(N)=CC3=C2C(C(N1CCN(C)C)=O)=CC=C3

Molecular Formula

C20H23N3O7

Molecular Weight

417.41

References & Citations

[1]Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20 (7) :995-1003.|[2]Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47 (4) :1040-4. |[3]Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6 (2) :79-85.