Tetraconazole

Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R) - (+) -Tetraconazole is 1.49-1.98 times more active than (S) - (-) -Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells[1][2][3].

Product Specifications

CAS Number

[112281-77-3]

UNSPSC

12352005

Hazard Statement

H400

Target

Fungal

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Purity

96.98

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC(F)C(F)(F)OCC(C1=CC=C(Cl)C=C1Cl)CN2N=CN=C2

Molecular Formula

C13H11Cl2F4N3O

Molecular Weight

372.15

Precautions

H400

References & Citations

[1]Tong Z, et al. Enantioselective effects of the chiral fungicide tetraconazole in wheat: Fungicidal activity and degradation behavior. Environ Pollut. 2019;247:1-8.|[2]Sieiro-Sampedro T, et al. Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds. Food Res Int. 2020;130:108930.|[3]Macar O. Multiple toxic effects of tetraconazole in Allium cepa L. meristematic cells. Environ Sci Pollut Res Int. 2021 Feb;28 (8) :10092-10099.