WB2838

WB2838 is a non-steroidal androgen-receptor antagonist (IC50: 0.8 μM for partially purified rat prostate cytosol receptor) . WB2838 exhibits anti-cancer activity against androgen-responsive breast cancer. WB2838 also shows the inhibitory activity against the growth of the ventral prostate induced by Testosterone propionate[1].

Product Specifications

CAS Number

[16386-65-5]

UNSPSC

12352005

Target

Androgen Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Endocrinology

Smiles

ClC1=CC=CC(=C1N)C2=CNC=C2Cl

Molecular Formula

C10H8Cl2N2

Molecular Weight

227.09

References & Citations

[1]HORI Y, et al. WB2838 [3-chloro-4- (2-amino-3-chlorophenyl) -pyrrole]: non-steroidal androgen-receptor antagonist produced by a Pseudomonas. The Journal of Antibiotics, 1993, 46 (9) : 1327-1333.