CAP 3

CAP 3 is a cholic acid-peptide conjugate (CAP) antimicrobial agent. CAP 3 effectively inhibits Gram-negative bacteria, with MIC99 (minimum inhibitory concentration for 99% bacterial killing) values of 8 μM, 16 μM, and 16 μM against E. coli, Klebsiella pneumoniae and Acinetobacter baumannii, respectively. CAP 3 exerts its antibacterial effects by disrupting the structural integrity of the bacterial lipopolysaccharide (LPS) outer membrane. CAP 3 rapidly kills bacteria, inhibits biofilm formation, and effectively combats drug-resistant strains and persistent bacterial infections[1].

Product Specifications

CAS Number

[2292123-03-4]

UNSPSC

12352211

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC(C)[C@H](N)C(NCC(O[C@H]1[C@]2([H])[C@@](C[C@@H]([C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCC(OCC4=CC=CC=C4)=O)C)OC(CNC([C@@H](N)C(C)C)=O)=O)([H])[C@@]5([C@](C[C@@H](CC5)OC(CNC([C@@H](N)C(C)C)=O)=O)([H])C1)C)=O)=O

Molecular Formula

C52H82N6O11

Molecular Weight

967.24

References & Citations

[1]Yadav K, et al. Deciphering the Role of Intramolecular Networking in Cholic Acid-Peptide Conjugates on the Lipopolysaccharide Surface in Combating Gram-Negative Bacterial Infections. J Med Chem. 2019 Feb 28;62 (4) :1875-1886.