NMac1

NMac1 is an orally active Nm23/NDPK activator. NMac1 directly binds to Nm23-H1 and activates the NDPK activity of recombinant Nm23-H1 with an EC50 of 10.7 uM. NMac1 induces AMPK activation and inhibits mTOR and ERK, leading to mitochondrial OXPHOS dysregulation and suppressing mitochondrial ROS production, which in turn induces mitochondrial dysfunction in MDA-MB-231 cells. NMac1 inhibits Complex I activity and suppresses changes in morphology and actin cytoskeleton organization following Rac1 activation in MDA-MB-231 cells. NMac1 inhibits tumor invasion, migration and metastasis. NMac1 is useful for studying metastatic tumors, such as breast cancer. NMac1 can be isolated from the ginger cassumunar Roxb[1][2].

Product Specifications

CAS Number

[1332290-68-2]

UNSPSC

12352005

Target

AMPK; ERK; mTOR; Oxidative Phosphorylation; Ras; Reactive Oxygen Species (ROS)

Related Pathways

Epigenetics; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

COC1=CC(/C=C/C2C(C3=CC=C(OC)C(OC)=C3)C=CCC2)=CC=C1OC

Molecular Formula

C24H28O4

Molecular Weight

380.48

References & Citations

[1]Kim B, et al. Nm23-H1 activator phenylbutenoid dimer exerts cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation. Sci Rep. 2021 Dec 7;11 (1) :23549.|[2]Lee JJ, et al. Small molecule activator of Nm23/NDPK as an inhibitor of metastasis. Sci Rep. 2018 Jul 19;8 (1) :10909.