VU0477573
VU0477573 is a brain-penetrant partial negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5) . VU0477573 exhibits neuroprotective and anxiolytic effects. VU0477573 can be used for the research of neurological disease, such as Parkinson disease[1].
Product Specifications
CAS Number
[1946021-40-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Purity
97.65
Smiles
O=C(N(CC)CC)C1=NC=C(C=C1)C#CC2=CC(F)=CC=C2
Molecular Formula
C18H17FN2O
Molecular Weight
296.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Nickols HH, et al. VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy. J Pharmacol Exp Ther. 2016 Jan;356 (1) :123-36.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Available Sizes
Curated Selection
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