RS-0406
RS-0406 is a beta-sheet breaker targeting Amyloid-β. RS-0406 can inhibits Aβ (1-42) fibrillogenesis and protect against Aβ (1-42) -induced cytotoxicity in primary hippocampal neurons. RS-0406 can be used for the research of neurological disease, such as Alzheimer's disease (AD) [1].
Product Specifications
CAS Number
[530112-00-6]
UNSPSC
12352005
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
OC1=CC=CC(NC2=NN=C(NC3=CC(O)=CC=C3)C=C2)=C1
Molecular Formula
C16H14N4O2
Molecular Weight
294.31
References & Citations
[1]Nakagami Y, et al. A novel beta-sheet breaker, RS-0406, reverses amyloid beta-induced cytotoxicity and impairment of long-term potentiation in vitro. Br J Pharmacol. 2002 Nov;137 (5) :676-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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