β-Naphthoflavone (Standard)

β-Naphthoflavone (Standard) is the analytical standard of β-Naphthoflavone. This product is intended for research and analytical applications. β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to treat aristolochic acid (AAI) induced renal injury[1][2][3].

Product Specifications

CAS Number

[6051-87-2]

UNSPSC

12352100

Target

Apoptosis; Aryl Hydrocarbon Receptor; Reference Standards

Related Pathways

Apoptosis; Immunology/Inflammation; Others

Field of Research

Cancer; Neurological Disease

Smiles

O=C1C2=C3C=CC=CC3=CC=C2OC(C4=CC=CC=C4)=C1

Molecular Formula

C19H12O2

Molecular Weight

272.30

References & Citations

[1]Ishida T, Takechi S. β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019;44 (10) :711-720.|[2]Zhu Y, et al. α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med. 2017 Mar;13 (3) :1143-1150. |[3]Ying Xiao, et al. β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta Pharmacologica Sinica 30.11 (2009) : 1559-1565.