BMS-694153

BMS-694153 is a potent antagonist of the human calcitonin gene-related peptide receptor (CGRP Receptor) . BMS-694153 can be used for migraine with rapid and efficient intranasal exposure[1].

Product Specifications

CAS Number

[1050381-35-5]

UNSPSC

12352005

Target

CGRP Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C1N(C2CCN(CC2)C(N[C@@H](C(N3CCC(N4CCCCC4)CC3)=O)CC5=CC(C)=C(NN=C6)C6=C5)=O)CC7=CC=CC(F)=C7N1

Molecular Formula

C35H45FN8O3

Molecular Weight

644.78

References & Citations

[1]Degnan AP, et al. Discovery of (R) -4- (8-fluoro-2-oxo-1,2-dihydroquinazolin-3 (4H) -yl) -N- (3- (7-methyl-1H-indazol-5-yl) -1-oxo-1- (4- (piperidin-1-yl) piperidin-1-yl) propan-2-yl) piperidine-1-carboxamide (BMS-694153) : a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. J Med Chem. 2008 Aug 28;51 (16) :4858-61.