ADN 138

ADN-138 is an aldose reductase inhibitor. ADN-138 reduces sorbitol levels in diabetic nerves and results in significant increases in MNCV and Na+, K+-ATPase in the nerves. ADN-138 can be used in the research of diabetic nerve complications[1].

Product Specifications

CAS Number

[99434-90-9]

UNSPSC

12352005

Target

Aldose Reductase; Endogenous Metabolite; Na+/K+ ATPase

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=C(N1)C2(CC1=O)C3=C4N(CCOC4=CC(Cl)=C3)C2=O

Molecular Formula

C13H9ClN2O4

Molecular Weight

292.67

References & Citations

[1]Hirata Y, Okada K. Relation of Na+, K (+) -ATPase to delayed motor nerve conduction velocity: effect of aldose reductase inhibitor, ADN-138, on Na+, K (+) -ATPase activity. Metabolism. 1990 Jun;39 (6) :563-7.