DS21412020

DS21412020 is a fluoroquinolone antibacterial agent. DS21412020 inhibits bacterial DNA gyrase (GyrA) and topoisomerase IV, leading to DNA breaks. DS21412020 exhibits significant activity against Gram-positive bacteria such as Staphylococcus aureus (MIC = 0.006 μg/mL), Streptococcus pneumoniae (MIC = 0.05 μg/mL), and Methicillin (HY-121544) -resistant Staphylococcus aureus (MIC = 0.2 μg/mL), and Gram-negative bacteria such as Escherichia coli (MIC = 0.006 μg/mL) and Pseudomonas aeruginosa (MIC = 0.78 μg/mL) . DS21412020 significantly reduces bacterial load in mouse pneumonia and MRSA infection models. DS21412020 can be used in the development of next-generation quinolone antibiotics[1].

Product Specifications

CAS Number

[1037366-37-2]

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis; Topoisomerase

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

O=C(O)C1=CN(C2=C(C1=O)C=C(C(N3C[C@]4(N)COCC[C@]4(C3)[H])=C2OC)F)[C@H]5[C@H](C5)F

Molecular Formula

C21H23F2N3O5

Molecular Weight

435.42

References & Citations

[1]Odagiri T, et al. Design, Synthesis, and Biological Evaluation of Novel 7-[ (3 aS,7 aS) -3 a-Aminohexahydropyrano[3,4- c]pyrrol-2 (3 H) -yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens. J Med Chem. 2018 Aug 23;61 (16) :7234-7244. doi: 10.1021/acs.jmedchem.8b00644. Epub 2018 Aug 8.