CH5137291
CH5137291 is an orally active pure antagonist of the androgen receptor (AR), without generating agonist metabolites. CCH5137291 directly blocks the transfer of AR from the cytoplasm to the nucleus. H5137291 can completely inhibit tumor growth in cells and mouse models of castration-resistant prostate cancer models. CH5137291 can be used for the study of castration-resistant prostate cancer (CRPC) [1][2].
Product Specifications
CAS Number
[1043446-39-4]
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
N#CC1=CC=C(N2C(C(C)(C)N(C2=S)C3=CC=CC(S(=O)(N)=O)=N3)=O)C=C1C(F)(F)F
Molecular Formula
C18H14F3N5O3S2
Molecular Weight
469.46
References & Citations
[1][2]
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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