AR-12463

AR-12463 is a derivative of Trapidil (HY-B1016) . AR-12463 inhibits the conversion of [14C]acetate to cholesterol. AR-12463 significantly reduces the elevation of total cholesterol in rabbit serum and prevents cholesterol incorporation into tissues. AR-12463 can be used to study atherosclerosis.

Product Specifications

CAS Number

[100557-04-8]

UNSPSC

12352005

Target

Drug Derivative; Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Smiles

OCCN(CCCCC)C1=CC(N2CCCCC2)=NC3=NC=NN31

Molecular Formula

C17H28N6O

Molecular Weight

332.44

References & Citations

[1]Beitz J, et al. Influence of the trapidil derivative AR 12463 on serum and tissue lipids and development of aortic lesions during experimental atherosclerosis in rabbits. Biomed Biochim Acta. 1991;50 (1) :101-7. PMID: 1859385.|[2]Beitz J, et al. Influence of the trapidil derivative AR 12463 on serum and tissue lipids and development of aortic lesions during experimental atherosclerosis in rabbits. Biomed Biochim Acta. 1991;50 (1) :101-7.