3-Hydroxyhippuric acid (Standard)

3-Hydroxyhippuric acid (Standard) is the analytical standard of 3-Hydroxyhippuric acid. This product is intended for research and analytical applications. 3-Hydroxyhippuric acid is an acyl glycine. 3-Hydroxyhippuric acid inhibits kynureninase (Ki = 60 μM) . 3-Hydroxyhippuric acid is found in higher concentrations in autistic group than in the controls. 3-Hydroxyhippuric acid is a marker of Clostridium species, and has a positive correlation with the level of Clostridia. 3-Hydroxyhippuric acid is one of the main metabolites formed from the catechin diet and wine polyphenol diets[1][2][3].

Product Specifications

CAS Number

[1637-75-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Purity

99.74

Smiles

O=C(O)CNC(C1=CC=CC(O)=C1)=O

Molecular Formula

C9H9NO4

Molecular Weight

195.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Xiong, X., et al., (2016) . Urinary 3- (3-Hydroxyphenyl) -3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders. BioMed research international, 2016, 9485412.|[2]Gonthier, M. P., et al., (2003) . Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols. The Journal of nutrition, 133 (2), 461–467.|[3]Lima, S., Kumar, S., (2009) . Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. Journal of medicinal chemistry, 52 (2), 389–396.