AN11736

AN11736 is a CPSF3 inhibitor. AN11736 exerts a potent anti-trypsin effect by specifically inhibiting the activity of the trypanosome CPSF3 endonuclease, disrupting the mRNA maturation process. AN11736 exhibits IC50s against T. congolense and T. vivax of 0.14 and 1.3 nM, respectively. AN11736 exhibits strong anti-trypsin activity in mouse and cattle models[1][2].

Product Specifications

CAS Number

[2152662-85-4]

UNSPSC

12352005

Target

MRNA; Parasite

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

OB1OCC2=CC=C(C(N[C@@H](C(C)C)C(OCC3=CC=C(F)C=C3)=O)=O)C(C)=C21

Molecular Formula

C21H23BFNO5

Molecular Weight

399.22

References & Citations

[1]Akama T, et al. Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT) . Bioorg Med Chem Lett. 2018 Jan 1;28 (1) :6-10.|[2]Wall RJ, et al. Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. Proc Natl Acad Sci U S A. 2018 Sep 18;115 (38) :9616-9621.