EXEL-0346
EXEL-0346 is an orally active glucosylceramide synthase (GCS) inhibitor, with an IC50 of 2 nM. EXEL-0346 combined with insulin increases pAkt. EXEL-0346 effectively reduces the levels of Glucosylceramide, Lactosylceramide and GM3. EXEL-0346 improves obesity and diabetes[1].
Product Specifications
CAS Number
[1239893-96-9]
UNSPSC
12352005
Target
Glucosylceramide Synthase (GCS)
Related Pathways
Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
O=C(C1(C2=CC=C(OC(F)(F)F)C=C2)CC1)N[C@@H](CC3=CC=C(Br)C=C3)C(N4C5CC(N)CC4CC5)=O
Molecular Formula
C27H29BrF3N3O3
Molecular Weight
580.44
References & Citations
[1]Richards S, et al. Discovery and characterization of an inhibitor of glucosylceramide synthase. J Med Chem. 2012 May 10;55 (9) :4322-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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