Ischemin

Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin also prevents apoptosis in ischemic cardiomyocytes. Ischemin can be used in the study of cardiovascular diseases (such as myocardial ischemia) [1].

Product Specifications

CAS Number

[1357059-00-7]

UNSPSC

12352005

Target

Apoptosis; Epigenetic Reader Domain; MDM-2/p53

Related Pathways

Apoptosis; Epigenetics

Field of Research

Cardiovascular Disease

Purity

99.8

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC(/N=N/C2=CC(C)=C(O)C=C2N)=C(C)C=C1C)(O)=O

Molecular Formula

C15H17N3O4S

Molecular Weight

335.38

References & Citations

[1]Borah JC, et al. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22;18 (4) :531-41.