SSM3 (tetraTFA)

SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro[1][2].

Product Specifications

CAS Number

[2320930-10-5]

UNSPSC

12352005

Target

Furin

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

N=C(N)NC(C=C1)=CC=C1O[C@@H]2[C@H](C[C@@H](NC(N)=N)[C@H](OC3=CC=C(NC(N)=N)C=C3)C2)NC(N)=N.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Molecular Formula

C30H36F12N12O10

Molecular Weight

952.66

References & Citations

[1]Albert G Remacle, et al. Selective and Potent Furin Inhibitors Protect Cells From Anthrax Without Significant Toxicity. Int J Biochem Cell Biol|[2]Guan-Sheng Jiao, et al. Synthetic Small Molecule Furin Inhibitors Derived From 2,5-dideoxystreptamine. Proc Natl Acad Sci U S A. 2006 Dec 26;103 (52) :19707-12.