Morphothiadin (mesylate)

Morphothiadin (GLS4) mesylate is a potent inhibitor of wild-type and Adefovir (HY-B1826) -resistant HBV replication with an IC50 value of 12 nM[1][2].

Product Specifications

CAS Number

[1646361-04-7]

Product Name Alternative

GLS4 (mesylate)

UNSPSC

12352005

Target

HBV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(C1=C(CN2CCOCC2)N=C(C3=NC=CS3)NC1C4=CC=C(C=C4Br)F)OCC.O=S(O)(C)=O

Molecular Formula

C22H26BrFN4O6S2

Molecular Weight

605.50

References & Citations

[1]Zhou X, et al. Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4, a novel anti-hepatitis B virus compound, in dogs. Acta Pharmacol Sin. 2013 Nov;34 (11) :1420-6. |[2]Wu G, et al. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother. 2013 Nov;57 (11) :5344-54.