PF-06767832

PF-06767832 is a potent muscarinic M1 selective positive allosteric modulator (PAM), with the EC50 of 60 nM. PF-06767832 has good brain penetration[1].

Product Specifications

CAS Number

[1859081-58-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MAChR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O[C@@H](COCC1)[C@H]1NC(C2=CC(CC3=CC=C(C4=CSC=N4)C=C3)=C(C)C=N2)=O

Molecular Formula

C22H23N3O3S

Molecular Weight

409.50

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jennifer E Davoren, et al. Discovery of the Potent and Selective M1 PAM-Agonist N-[ (3R,4S) -3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4- (1,3-thiazol-4-yl) benzyl]pyridine-2-carboxamide (PF-06767832) : Evaluation of Efficacy and Cholinergic Side Effects. J Med Chem. 2016 Jul 14;59 (13) :6313-28.