PF-05020182
PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC50 of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable[1].
Product Specifications
CAS Number
[1354712-92-7]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
O=C(CC(C)(C)C)NC1=C(OC)N=C(N2CCC(CC2)OC)N=C1OC
Molecular Formula
C18H30N4O4
Molecular Weight
366.46
References & Citations
[1]Davoren JE, et al., Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett. 2015 Nov 1;25 (21) :4941-4944.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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