A-348441

A-348441 is a liver selective glucocorticoid receptor antagonist. A-348441 can reduce the glucose level in the liver. A-348441 can be used for the research of metabolic disease, such as type 2 diabetes[1].

Product Specifications

CAS Number

[639520-46-0]

UNSPSC

12352005

Target

Glucocorticoid Receptor

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Smiles

C[C@@]12[C@](CC[C@@]2(O)C#CC)([H])[C@@]3([H])C([C@@H](C4=CC=C(N(C)CCO[C@@H]5C[C@]6([H])[C@@](C)([C@]7([H])[C@@]([C@@]8([H])[C@@](C)([C@]([C@H](C)CCC(O)=O)([H])CC8)[C@@H](O)C7)([H])[C@H](O)C6)CC5)C=C4)C1)=C9C(CC3)=CC(CC9)=O

Molecular Formula

C54H75NO7

Molecular Weight

850.18

References & Citations

[1]Edgerton DS, et al. Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production. Metabolism. 2006 Sep;55 (9) :1255-62.