AA 344

AA 344 is an orally active antiallergic agent. AA 344 inhibits the IgE, IgGa, Concanavalin A (HY-P2149), Dextran -mediated release of histamine. AA 344 shows inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. AA 344 selectively suppresses the type I allergic reaction[1][2].

Product Specifications

CAS Number

[50743-49-2]

UNSPSC

12352005

Target

Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Inflammation/Immunology

Smiles

O=C1C(C2=NN=NN2)=COC3=CC=C(CC)C=C13

Molecular Formula

C12H10N4O2

Molecular Weight

242.23

References & Citations

[1]Saijo T, et al. Inhibitory action of 6-ethyl-3- (1H-tetrazol-5-YL) chromone (AA-344) on IgE, IgGa- or chemical agent-induced histamine release from isolated rat mast cells. Jpn J Pharmacol. 1979 Aug;29 (4) :531-40.|[2]Kuriki H, et al. Effect of 6-ethyl-3- (1H-tetrazol-5-yl) chromone (AA-344) on the immediate and delayed hypersensitivity reactions. Jpn J Pharmacol. 1979 Oct;29 (5) :733-44.