PD 161374
PD 161374 is an inhibitor targeting the HIV-1 nucleocapsid protein NCp7. PD 161374 primarily acts on the early stages of viral replication, inhibiting the completion of reverse transcription without affecting viral entry or later assembly. PD 161374 remains active against HIV-1, HIV-2, SIV, and drug-resistant strains. PD 161374 can be used to study antiretroviral agents[1][2].
Product Specifications
CAS Number
[177785-47-6]
UNSPSC
12352005
Target
HIV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
CC[C@H](C)[C@H](N1SC2=CC=CC=C2C1=O)C(O)=O
Molecular Formula
C13H15NO3S
Molecular Weight
265.33
References & Citations
[1]Sharmeen L, et al. Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374. Antiviral Res. 2001 Feb;49 (2) :101-14.|[2]Ouhtit A. Synthesis and anti-retroviral activity of novel 1, 2-benzisothiazol-3 (2H) -one benzenesulfonamides targeting the HIV nucleocapsid protein 7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1; HIV-2
Curated Selection
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