Pacrinolol

Pacrinolol (HOE 224) is a selective and orally active beta1 adrenergic receptor blocker. Pacrinolol can inhibit Isoprenaline (HY-108353) -induced positive inotropic effect and increased heart rate. Pacrinolol can be used for the research of cardiovascular disease[1].

Product Specifications

CAS Number

[65655-59-6]

Product Name Alternative

HOE 224

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

COC1=C(C=C(CCNCC(O)COC2=CC=C(/C(C)=C/C#N)C=C2)C=C1)OC

Molecular Formula

C23H28N2O4

Molecular Weight

396.48

References & Citations

[1]Lindner E. L-3,4- (3-3,4-dimethoxyphenethylamino-2-hydroxypropoxy) -phenyl- crotonic acid nitrile.HCl (Hoe 224), a beta-blocking agent with high beta 1-selectivity. Arzneimittelforschung. 1984;34 (3) :270-6.