Niludipine

Niludipine (Bay a 7168) is an orally active calcium channel blocker and vasodilator with antihypertensive effects. Niludipine can improve early fatal ventricular arrhythmias induced by acute myocardial ischemia in rats. Niludipine can reduce left ventricular systolic and diastolic loads during pacing-induced angina pectoris. Niludipine can be used in the research of cardiovascular diseases such as coronary heart disease and myocardial ischemia[1][2].

Product Specifications

CAS Number

[22609-73-0]

Product Name Alternative

Bay a 7168

UNSPSC

12352005

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

CCCOCCOC(C1=C(C)NC(C)=C(C(OCCOCCC)=O)C1C2=CC([N+]([O-])=O)=CC=C2)=O

Molecular Formula

C25H34N2O8

Molecular Weight

490.55

References & Citations

[1]Kurita A, et al. Effects of new calcium channel blocker of niludipine on the coronary hemodynamics, diastolic properties, and metabolic responses to tachycardia stress in patients with coronary disease. Cathet Cardiovasc Diagn. 1982;8 (4) :373-81.|[2]Fagbemi O, et al. Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemia. Br J Pharmacol. 1981 Sep;74 (1) :12-4.