U 92032
U 92032 is a T-type Ca2+ channel antagonist. U 92032 inhibits Na+ channels. U-92032 inhibits thalamic oscillations. U 92032 can be used in the research of neurological diseases[1].
Product Specifications
CAS Number
[142223-92-5]
UNSPSC
12352005
Target
Calcium Channel; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1C(=CC(=CC=C1CN2CCN(CC2)C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C(C)C)NCCO
Molecular Formula
C30H35F2N3O2
Molecular Weight
507.63
References & Citations
[1]Porcello DM, et al. Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I (T) and slow intrathalamic rhythms. J Neurophysiol. 2003 Jan;89 (1) :177-85.|[2]Avery RB, et al. Ca2+ channel antagonist U-92032 inhibits both T-type Ca2+ channels and Na+ channels in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1997 Feb;77 (2) :1023-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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